Induction of hepatic xenobiotic metabolizing enzymes in female Fischer- 344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5)
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منابع مشابه
Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5).
Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. The present study was designed to investigate the effects of D5 on the expression and activity of selected rat hepatic phase I and phase II metabolizing enzymes. Female Fischer-344 rats were exposed to 160 ppm D5 vapors (6 h/day, 7 days/week, for 28 days) by whole-body inhalation. Changes in the...
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D5 is a low-molecular-weight cyclic siloxane used for industrial and consumer product applications. The objective of the present study was to assess potential toxic and immunomodulatory consequences of inhalation exposure to D5. Male and female Fischer 344 rats (25/group) were exposed by whole body inhalation to 0, 10, 25, 75, or 160 ppm D5 6 h/day, 7 days/week for 28 days. Clinical signs, body...
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The retention, distribution, metabolism, and excretion of [C]octamethylcyclotetrasiloxane (D4) were studied in Fischer 344 rats after single and multiple exposures to 7, 70, or 700 ppm [C]D4. Subset groups were established for body burden, distribution, and elimination. Retention of inhaled D4 was relatively low (5–6% of inhaled D4). Radioactivity derived from [ C]D4 inhalation was widely distr...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1999
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/50.1.10